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DeCS
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Descriptor English:
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5-Aminolevulinate Synthetase
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Descriptor Spanish:
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5-Aminolevulinato Sintetasa
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Descriptor Portuguese:
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5-Aminolevulinato Sintetase
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Synonyms English:
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Aminolevulinic Acid Synthetase
delta-Aminolevulinate Synthase
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Tree Number:
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D08.811.913.050.276
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Definition English:
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An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. |
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History Note English:
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98(72)
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Allowable Qualifiers English:
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Record Number:
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634
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Unique Identifier:
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D000624
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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